abstract：BACKGROUND:The natural history of coronary artery aneurysms (CAA) after intravenous immunoglobulin (IVIG) treatment in the United States is not well described. We describe the natural history of CAA in US Kawasaki disease (KD) patients and identify factors associated with major adverse cardiac events (MACE) and CAA reg...

journal_title：Journal of the American Heart Association

authors： Friedman KG,Gauvreau K,Hamaoka-Okamoto A,Tang A,Berry E,Tremoulet AH,Mahavadi VS,Baker A,deFerranti SD,Fulton DR,Burns JC,Newburger JW

更新日期：2016-09-15 00:00:00

abstract：BACKGROUND:In-stent hyperplasia (ISH) may develop in regions of low endothelial shear stress (ESS), but the relationship between the magnitude of low ESS, the extent of ISH, and subsequent clinical events has not been investigated. METHODS AND RESULTS:We assessed the association of poststent ESS with neointimal ISH an...

journal_title：Journal of the American Heart Association

authors： Shishido K,Antoniadis AP,Takahashi S,Tsuda M,Mizuno S,Andreou I,Papafaklis MI,Coskun AU,O'Brien C,Feldman CL,Saito S,Edelman ER,Stone PH

更新日期：2016-09-14 00:00:00

abstract：BACKGROUND:Intravascular imaging can facilitate chronic total occlusion (CTO) percutaneous coronary intervention. METHODS AND RESULTS:We examined the frequency of use and outcomes of intravascular imaging among 619 CTO percutaneous coronary interventions performed between 2012 and 2015 at 7 US centers. Mean age was 65...

journal_title：Journal of the American Heart Association

authors： Karacsonyi J,Alaswad K,Jaffer FA,Yeh RW,Patel M,Bahadorani J,Karatasakis A,Danek BA,Doing A,Grantham JA,Karmpaliotis D,Moses JW,Kirtane A,Parikh M,Ali Z,Lombardi WL,Kandzari DE,Lembo N,Garcia S,Wyman MR,Alame A,

更新日期：2016-08-20 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) carries high risk for short-term mortality. We sought to identify race-specific predictors of mortality in ICH patients. METHODS AND RESULTS:We used 2 databases, the Johns Hopkins clinical stroke database and the Nationwide Inpatient Sample (NIS). We included 226 patients with...

journal_title：Journal of the American Heart Association

authors： Faigle R,Marsh EB,Llinas RH,Urrutia VC,Gottesman RF

更新日期：2016-08-16 00:00:00

abstract：BACKGROUND:Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long-term venous graft patency secondary to intimal hyperplasia (IH) caused by venous injury upon exposure to arterial pressure. We investigate whether photochemical tissu...

journal_title：Journal of the American Heart Association

authors： Goldstone RN,McCormack MC,Khan SI,Salinas HM,Meppelink A,Randolph MA,Watkins MT,Redmond RW,Austen WG Jr

更新日期：2016-07-27 00:00:00

abstract：BACKGROUND:Ethnicity is an important predictor of coronary artery bypass graft surgery (CABG) outcomes. South Asians (SA), one of the largest ethnic groups with a high burden of cardiovascular disease, are hypothesized to have inferior outcomes after CABG compared to other ethnic groups. Given the paucity and controver...

journal_title：Journal of the American Heart Association

authors： Deb S,Tu JV,Austin PC,Ko DT,Rocha R,Mazer CD,Kiss A,Fremes SE

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:Cryoballoon pulmonary vein isolation (PVI) has emerged as an alternative to radiofrequency PVI for atrial fibrillation (AF). Data are lacking to define the rates and predictors of complications, particularly phrenic nerve injury (PNI). METHODS AND RESULTS:We evaluated a single-center prospective registry of...

journal_title：Journal of the American Heart Association

authors： Guhl EN,Siddoway D,Adelstein E,Bazaz R,Mendenhall GS,Nemec J,Saba S,Schwartzman D,Voigt A,Wang NC,Jain SK

更新日期：2016-07-21 00:00:00

abstract：BACKGROUND:Intracranial aneurysms (IAs), abdominal aortic aneurysms (AAAs), and thoracic aortic aneurysms (TAAs) all have a familial predisposition. Given that aneurysm types are known to co-occur, we hypothesized that there may be shared genetic risk factors for IAs, AAAs, and TAAs. METHODS AND RESULTS:We performed a...

journal_title：Journal of the American Heart Association

authors： van 't Hof FN,Ruigrok YM,Lee CH,Ripke S,Anderson G,de Andrade M,Baas AF,Blankensteijn JD,Böttinger EP,Bown MJ,Broderick J,Bijlenga P,Carrell DS,Crawford DC,Crosslin DR,Ebeling C,Eriksson JG,Fornage M,Foroud T,von Un

更新日期：2016-07-14 00:00:00

abstract：BACKGROUND:This study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery. METHODS AND RESULTS:Carotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3-hydroxy-3-met...

journal_title：Journal of the American Heart Association

authors： Sandfort V,Lai S,Ahlman MA,Mallek M,Liu S,Sibley CT,Turkbey EB,Lima JA,Bluemke DA

更新日期：2016-07-13 00:00:00

abstract：BACKGROUND:Quercetin, the most abundant dietary flavonol, has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. We assessed the impact of quercetin on BP through a systematic review and meta-analysis of available randomized controlled t...

journal_title：Journal of the American Heart Association

authors： Serban MC,Sahebkar A,Zanchetti A,Mikhailidis DP,Howard G,Antal D,Andrica F,Ahmed A,Aronow WS,Muntner P,Lip GY,Graham I,Wong N,Rysz J,Banach M,Lipid and Blood Pressure Meta‐analysis Collaboration (LBPMC) Group.

更新日期：2016-07-12 00:00:00

abstract：BACKGROUND:The mechanisms behind the association of atrial fibrillation (AF) and dementia are unknown. We previously found a significantly increased risk of dementia in AF patients taking warfarin with a low percentage of time in therapeutic range. The purpose of this study was to determine the extent to which AF itsel...

journal_title：Journal of the American Heart Association

authors： Bunch TJ,May HT,Bair TL,Crandall BG,Cutler MJ,Day JD,Jacobs V,Mallender C,Osborn JS,Stevens SM,Weiss JP,Woller SC

更新日期：2016-07-11 00:00:00

abstract：BACKGROUND:Kawasaki disease (KD) is a pediatric vasculitis with coronary artery aneurysm (CAA) as a major complication. Controversy exists about cardiovascular risk later in life. The aim of our study was to evaluate whether KD patients are at increased risk, as assessed by carotid intima-media thickness (cIMT). METHO...

journal_title：Journal of the American Heart Association

authors： Dietz SM,Tacke CE,de Groot E,Kuipers IM,Hutten BA,Kuijpers TW,Dutch Kawasaki Study Groupten BergeMaartjeBiezeveldMaarten H.BruijnMartijnDelemarreLuçan C.DolmanKoert M.FilippiniLuc H.P.M.HendriksTomMaingay‐VisserDianne A.P.G.F.NoordzijJeroen

更新日期：2016-07-05 00:00:00

abstract：BACKGROUND:Workforce experts predict a future shortage of cardiologists that is expected to impact rural areas more severely than urban areas. However, there is little research on how rural patients are currently served through clinical outreach. This study examines the impact of cardiology outreach in Iowa, a state wi...

journal_title：Journal of the American Heart Association

authors： Gruca TS,Pyo TH,Nelson GC

更新日期：2016-06-30 00:00:00

abstract：BACKGROUND:The postnatal development of myofibrillar mechanics, a major determinant of heart function, is unknown in pediatric patients with tetralogy of Fallot and related structural heart defects. We therefore determined the mechanical properties of myofibrils isolated from right ventricular tissue samples from such ...

journal_title：Journal of the American Heart Association

authors： Elhamine F,Iorga B,Krüger M,Hunger M,Eckhardt J,Sreeram N,Bennink G,Brockmeier K,Pfitzer G,Stehle R

更新日期：2016-06-27 00:00:00

abstract：BACKGROUND:Recent studies have shown improving survival after cardiac arrest. However, data regarding sex-based disparities in treatment and outcomes after cardiac arrest are limited. METHODS AND RESULTS:We performed a retrospective analysis of all patients suffering cardiac arrest between 2003 and 2012 using the Nati...

journal_title：Journal of the American Heart Association

authors： Kim LK,Looser P,Swaminathan RV,Horowitz J,Friedman O,Shin JH,Minutello RM,Bergman G,Singh H,Wong SC,Feldman DN

更新日期：2016-06-22 00:00:00

abstract：BACKGROUND:Cardiovascular clinical trials depend on patient enrollment. Enrollment rates appear inadequate, but little is known about how frequently patients accept or decline offers of enrollment. The objective of this study was to assess trends and predictors of patient acceptance of offers to enroll in clinical tria...

journal_title：Journal of the American Heart Association

authors： Kerkhoff LA,Butler J,Kelkar AA,Shore S,Speight CD,Wall LK,Dickert NW

更新日期：2016-06-17 00:00:00

abstract：BACKGROUND:Light chain amyloidosis (AL) is associated with high mortality, especially in patients with advanced cardiovascular involvement. It is caused by toxicity of misfolded light chain proteins (LC) in vascular, cardiac, and other tissues. There is no treatment to reverse LC tissue toxicity. We tested the hypothes...

journal_title：Journal of the American Heart Association

authors： Franco DA,Truran S,Weissig V,Guzman-Villanueva D,Karamanova N,Senapati S,Burciu C,Ramirez-Alvarado M,Blancas-Mejia LM,Lindsay S,Hari P,Migrino RQ

更新日期：2016-06-13 00:00:00

abstract：BACKGROUND:Despite guideline recommendations, a significant number of patients with non-ST elevation myocardial infarction (NSTEMI) do not receive dual antiplatelet therapy (DAPT) before angiography "pretreatment." While there may be valid clinical reasons to not pretreat, such as concern for bleeding or multivessel di...

journal_title：Journal of the American Heart Association

authors： Shafiq A,Valle J,Jang JS,Qintar M,Gosch K,Cohen DJ,Singh M,Bach R,Spertus JA

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:A higher milk consumption may be associated with a lower stroke risk. We conducted a comprehensive systematic review and dose-response meta-analysis of milk and other dairy products in relation to stroke risk. METHODS AND RESULTS:Through a systematic literature search, prospective cohort studies of dairy fo...

journal_title：Journal of the American Heart Association

authors： de Goede J,Soedamah-Muthu SS,Pan A,Gijsbers L,Geleijnse JM

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Statin therapy reduces the risk of cardiovascular events in patients with obstructive coronary artery disease. The aim of the present study was to determine the effects of statins on the prognosis of patients with coronary vasospastic angina (VSA) free of significant atherosclerotic stenosis. METHODS AND RE...

journal_title：Journal of the American Heart Association

authors： Ishii M,Kaikita K,Sato K,Yamanaga K,Miyazaki T,Akasaka T,Tabata N,Arima Y,Sueta D,Sakamoto K,Yamamoto E,Tsujita K,Yamamuro M,Kojima S,Soejima H,Hokimoto S,Matsui K,Ogawa H

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Time-limited acute stroke treatments are underused, primarily due to prehospital delay. One approach to decreasing prehospital delay is to increase stroke preparedness, the ability to recognize stroke, and the intention to immediately call emergency medical services, through community engagement with high-ri...

journal_title：Journal of the American Heart Association

authors： Skolarus LE,Zimmerman MA,Bailey S,Dome M,Murphy JB,Kobrossi C,Dombrowski SU,Burke JF,Morgenstern LB

更新日期：2016-05-20 00:00:00

abstract：BACKGROUND:Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (AMI). To elucidate the mechanisms underlying the association of ALDH2*2 ...

journal_title：Journal of the American Heart Association

authors： Mizuno Y,Hokimoto S,Harada E,Kinoshita K,Nakagawa K,Yoshimura M,Ogawa H,Yasue H

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30-day page views. Whether insufficient social media intensity contributed to these results is uncertain. METHODS AND RESULTS:Original article manuscripts were randomized to social media...

journal_title：Journal of the American Heart Association

authors： Fox CS,Gurary EB,Ryan J,Bonaca M,Barry K,Loscalzo J,Massaro J

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:The structure of the aorta is considered to influence exercise systolic blood pressure (SBP) response, which, in turn, might impact upon adverse outcomes. The current study sought to investigate the relationship of aortic calcification and exercise SBP with adverse outcomes among elderly individuals. METHOD...

journal_title：Journal of the American Heart Association

authors： Cho IJ,Chang HJ,Cho I,Heo R,Lee SE,Shim CY,Hong GR,Chung N

更新日期：2016-04-22 00:00:00

abstract：BACKGROUND:Although generic medications are approved based on bioequivalence with brand-name medications, there remains substantial concern regarding their clinical effectiveness and safety. Lipitor(®), available as generic atorvastatin, is one of the most commonly prescribed statins. Therefore, we compared the effecti...

journal_title：Journal of the American Heart Association

authors： Jackevicius CA,Tu JV,Krumholz HM,Austin PC,Ross JS,Stukel TA,Koh M,Chong A,Ko DT

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Although clinical trials have proved that statin can be used prophylactically against cardiovascular events, the direct effects of statin on plaque development are not well understood. We generated low-density lipoprotein receptor knockout (LDLR(-/-)) pigs to study the effects of early statin administration ...

journal_title：Journal of the American Heart Association

authors： Li Y,Fuchimoto D,Sudo M,Haruta H,Lin QF,Takayama T,Morita S,Nochi T,Suzuki S,Sembon S,Nakai M,Kojima M,Iwamoto M,Hashimoto M,Yoda S,Kunimoto S,Hiro T,Matsumoto T,Mitsumata M,Sugitani M,Saito S,Hirayama A,Onish

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:Despite variations in the prevalence of cardiovascular disease and related risk factors among US Hispanic/Latino adults of diverse backgrounds, there is little information on whether disparities exist in the use of medications for the primary and secondary prevention of cardiovascular disease. We examined th...

journal_title：Journal of the American Heart Association

authors： Qato DM,Lee TA,Durazo-Arvizu R,Wu D,Wilder J,Reina SA,Cai J,Gonzalez F 2nd,Talavera GA,Ostfeld RJ,Daviglus ML

更新日期：2016-03-30 00:00:00

abstract：BACKGROUND:Ischemic stroke is a major cause of death and disability in the world. A major ischemic stroke subtype, large-vessel ischemic stroke (large artery atherosclerosis; LAA), has been shown to have some genetic components in individuals of European ancestry. However, it is not clear whether the genetic predisposi...

journal_title：Journal of the American Heart Association

authors： Lee TH,Ko TM,Chen CH,Lee MT,Chang YJ,Chang CH,Huang KL,Chang TY,Lee JD,Chang KC,Yang JT,Wen MS,Wang CY,Chen YT,Hsieh CS,Chou SY,Liu YM,Chen HW,Liao HT,Wang CW,Chen SP,Lu LS,Chen YT,Wu JY

更新日期：2016-03-29 00:00:00

abstract：BACKGROUND:Recent literature suggests that blood pressure variability (BPV) predicts outcome beyond blood pressure level (BPL) and that antihypertensive drug classes differentially influence BPV. We compared calcium channel blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockade for effect...

journal_title：Journal of the American Heart Association

authors： Asayama K,Ohkubo T,Hanazawa T,Watabe D,Hosaka M,Satoh M,Yasui D,Staessen JA,Imai Y,Hypertensive Objective Treatment Based on Measurement by Electrical Devices of Blood Pressure (HOMED‐BP) Study Investigators.

更新日期：2016-03-23 00:00:00

abstract：BACKGROUND:Treatment decisions for aortic valve replacement (AVR) should be sensitive to patient preferences. However, we lack knowledge of patient preferences and how to obtain them. METHODS AND RESULTS:We assessed the mortality risk patients were willing to accept when undergoing AVR by using the Standard Gamble met...

journal_title：Journal of the American Heart Association

authors： Hussain AI,Garratt AM,Brunborg C,Aakhus S,Gullestad L,Pettersen KI

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:The geometric organization of myocytes in the ventricular wall comprises the structural underpinnings of cardiac mechanical function. Cardiac myosin binding protein-C (MYBPC3) is a sarcomeric protein, for which phosphorylation modulates myofilament binding, sarcomere morphology, and myocyte alignment in the ...

journal_title：Journal of the American Heart Association

authors： Taylor EN,Hoffman MP,Barefield DY,Aninwene GE 2nd,Abrishamchi AD,Lynch TL 4th,Govindan S,Osinska H,Robbins J,Sadayappan S,Gilbert RJ

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:No data are available on the long-term performance of ultrathin strut biodegradable polymer sirolimus-eluting stents (BP-SES). We reported 2-year clinical outcomes of the BIOSCIENCE (Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting Stent Versus Durable Polymer Everolimus-Eluting Stent for Percutaneous...

journal_title：Journal of the American Heart Association

authors： Zbinden R,Piccolo R,Heg D,Roffi M,Kurz DJ,Muller O,Vuilliomenet A,Cook S,Weilenmann D,Kaiser C,Jamshidi P,Franzone A,Eberli F,Jüni P,Windecker S,Pilgrim T

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers i...

journal_title：Journal of the American Heart Association

authors： Engblom H,Heiberg E,Erlinge D,Jensen SE,Nordrehaug JE,Dubois-Randé JL,Halvorsen S,Hoffmann P,Koul S,Carlsson M,Atar D,Arheden H

更新日期：2016-03-09 00:00:00

abstract：BACKGROUND:Excess accumulation of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT) is associated with adverse levels of adipokines and cardiovascular disease risk. Whether fat quality is associated with adipokines has not been firmly established. This study examined the association between abdominal SAT a...

journal_title：Journal of the American Heart Association

authors： Lee JJ,Pedley A,Hoffmann U,Massaro JM,Keaney JF Jr,Vasan RS,Fox CS

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Metropolitan versus nonmetropolitan status and area median income may independently affect care for and outcomes of acute coronary syndromes. We sought to determine whether location of care modifies the association among area income, receipt of cardiac catheterization, and mortality following an acute corona...

journal_title：Journal of the American Heart Association

authors： Fabreau GE,Leung AA,Southern DA,James MT,Knudtson ML,Ghali WA,Ayanian JZ

更新日期：2016-02-23 00:00:00

abstract：BACKGROUND:Studies have suggested that patients with atrial fibrillation (AF) have impairment in the baroreflex. It is not clear whether these findings are the result of the associated comorbid conditions or the arrhythmia itself. We hypothesized that AF is associated with impairment in baroreflex function and that the...

journal_title：Journal of the American Heart Association

authors： Field ME,Wasmund SL,Page RL,Hamdan MH

更新日期：2016-02-23 00:00:00

abstract：BACKGROUND:Pediatric syncope is common. Cardiac causes are rarely found. We describe and assess a pragmatic approach to these patients first seen by a pediatric cardiologist in the New England region, using Standardized Clinical Assessment and Management Plans (SCAMPs). METHODS AND RESULTS:Ambulatory patients aged 7 t...

journal_title：Journal of the American Heart Association

authors： Paris Y,Toro-Salazar OH,Gauthier NS,Rotondo KM,Arnold L,Hamershock R,Saudek DE,Fulton DR,Renaud A,Alexander ME,New England Congenital Cardiology Association (NECCA).

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Metabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndro...

journal_title：Journal of the American Heart Association

authors： Deen JF,Krieger EV,Slee AE,Arslan A,Arterburn D,Stout KK,Portman MA

更新日期：2016-02-12 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is a common, growing, and costly medical condition. We aimed to evaluate the impact of a management algorithm for symptomatic AF that used an emergency department observation unit on hospital admission rates and patient outcomes. METHODS AND RESULTS:This retrospective cohort study c...

journal_title：Journal of the American Heart Association

authors： Bellew SD,Bremer ML,Kopecky SL,Lohse CM,Munger TM,Robelia PM,Smars PA

更新日期：2016-02-08 00:00:00

abstract：BACKGROUND:Epidemiological evidence suggests a cardioprotective role of α-linolenic acid (ALA), a plant-derived ω-3 fatty acid. It is unclear whether ALA is beneficial in a background of high marine ω-3 fatty acids (long-chain n-3 polyunsaturated fatty acids) intake. In persons at high cardiovascular risk from Spain, a...

journal_title：Journal of the American Heart Association

authors： Sala-Vila A,Guasch-Ferré M,Hu FB,Sánchez-Tainta A,Bulló M,Serra-Mir M,López-Sabater C,Sorlí JV,Arós F,Fiol M,Muñoz MA,Serra-Majem L,Martínez JA,Corella D,Fitó M,Salas-Salvadó J,Martínez-González MA,Estruch R,Ros E,P

更新日期：2016-01-26 00:00:00